The Role of Genetic Screening (PGT-A/PGT-M) in Modern IVF Success
Medically Reviewed by Dr. B. Angelynn Singh
Director, FaithStep Fertility Clinic | MBBS, DNB, Obstetrics & Gynaecology, Advanced Diploma in ART & Reproductive Medicine( Kiel, Germany) Visiting Consultant: BLK-Max Super Speciality & Max Healthcare | Published: October 2026Pre-implantation Genetic Testing (PGT-A for aneuploidies; PGT-M for monogenic hereditary disorders) involves biopsying 4 to 6 cells from a Day 5 blastocyst's trophectoderm to screen for chromosomal abnormalities prior to transfer. Transferring genetically confirmed euploid embryos elevates clinical pregnancy rates to 70%–75% and significantly curtails miscarriage risks in women over 35.
1. Clinical Context & Patient Understanding
Embarking on a fertility journey is both an emotional and medical endeavor. With Dr. B. Angelynn Singh's 23+ years of reproductive clinical experience leading FaithStep Fertility Clinic in Karol Bagh, New Delhi, we witness how often couples struggle with fragmented advice, opaque corporate pricing, and overwhelming clinical jargon.
Whether you reside in Karol Bagh, Patel Nagar, Connaught Place, South Extension, or commute from Noida or Gurgaon, understanding the physiological reality of your treatment is your greatest asset.
2. In-Depth Medical Evaluation & Evidence-Based Insights
Modern reproductive medicine relies on microscopic precision. At FaithStep, protocols developed through advanced Indian and European training at Delhi India & Kiel Germany are applied to every cycle:
- Individualized Ovarian Protocols: Avoiding generic 'cookie-cutter' stimulation; hormone dosing is calibrated to antral follicle counts, baseline AMH, and previous response markers.
- Advanced Cleanroom Embryology: Maintaining Class 10,000 air quality, low-oxygen tri-gas benchtop incubators, and strict temperature stability to ensure embryos reach the Day 5/6 blastocyst stage without cellular stress.
- Personalized Procedural Hands-on Care: Dr. B. Angelynn Singh personally evaluates every scan, follicular dynamic, and delicate embryo placement—eliminating the common pitfall of corporate hospital chains where junior residents rotate through delicate procedures.
Have Questions About Your Specific Medical Case?
Discuss your hormonal reports, semen analysis, or previous cycle history in complete privacy directly with Dr. B. Angelynn Singh.
3. Comparing Treatment Pathways: Making Informed Choices
Couples often wonder whether to proceed with conservative management, timed intrauterine insemination (IUI), or advanced in-vitro fertilization (IVF) paired with ICSI. The decision requires clear diagnostic benchmarks:
- Diagnostic Patency: Evaluating fallopian tube health and uterine cavity contouring via 3D ultrasound or diagnostic hysteroscopy.
- Sperm Functional Competence: Beyond macroscopic count and motility, testing sperm DNA integrity (DFI) ensures optimal fertilization.
- Endometrial Synchronization: Ensuring optimal triple-line endometrial thickness (>7.5–8mm) with healthy uterine vascular perfusion before embryo transfer.
4. Localized Realities: Navigating Fertility Care in Delhi NCR
Couples living across Delhi NCR face specific urban considerations:
Work-Life Balance: Balancing intense corporate schedules in Gurgaon or Connaught Place with time-sensitive monitoring. FaithStep accommodates patients with early-morning appointment slots and rapid 20-minute ultrasound visits.
Financial Transparency: Avoiding deceptive hospital packages where 'base rates' hide essential stimulation drugs, freezing, and OT charges. FaithStep guarantees 100% itemized, honest financial disclosures upfront.
Convenient Central Commute: Our clinic is centrally located on New Rohtak Road, directly opposite Liberty Cinema, merely 400 meters from Karol Bagh Metro Station (Blue Line) with convenient doorstep access from across West, South, East Delhi, and NCR.
5. Frequently Asked Questions
Does biopsy for PGT damage the developing baby?
No. The biopsy takes cells exclusively from the outer trophectoderm (which becomes the placenta), leaving the inner cell mass (which becomes the fetus) completely untouched.
Who benefits most from PGT-A screening?
Women aged 35 and older, couples with recurrent miscarriages, patients with previous failed IVF cycles, and carriers of chromosomal structural translocations.
Can PGT test for specific inherited family conditions like Thalassemia?
Yes! PGT-M (Monogenic) is custom-designed to screen for specific single-gene genetic disorders such as Thalassemia, Cystic Fibrosis, and Huntington's Disease.
Ready to Take Your FaithStep Journey Towards Parenthood?
Visit Dr. B. Angelynn Singh at FaithStep Fertility Clinic in Karol Bagh, New Delhi. Experience senior clinical precision, ethical care, and transparent pricing.